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Synergistic targeting and resistance to PARP inhibition in pancreatic cancer
To cite: Gout J, Perkhofer L, Morawe M, et al. Gut 2021;70:743-760.
Read the full article here: link
Objective: ATM serine/threonine kinase (ATM) is the most frequently mutated DNA damage response gene, involved in homologous recombination (HR), in pancreatic ductal adenocarcinoma (PDAC).
Conclusion: Analysis of the molecular susceptibilities triggered by ATM deficiency in PDAC allow elaboration of an efficient mutation-specific combinational therapeutic approach that can be also implemented in a genotype-independent manner by ATM inhibition.